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<StructureSection load='5acb' size='340' side='right'caption='[[5acb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5acb' size='340' side='right'caption='[[5acb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5acb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ACB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ACB FirstGlance]. <br>
<table><tr><td colspan='2'>[[5acb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ACB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ACB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5I1:N-[4-[(3R)-3-[[5-CHLORANYL-4-(1H-INDOL-3-YL)PYRIMIDIN-2-YL]AMINO]PIPERIDIN-1-YL]CARBONYLPHENYL]-4-(DIMETHYLAMINO)BUTANAMIDE'>5I1</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5I1:N-[4-[(3R)-3-[[5-CHLORANYL-4-(1H-INDOL-3-YL)PYRIMIDIN-2-YL]AMINO]PIPERIDIN-1-YL]CARBONYLPHENYL]-4-(DIMETHYLAMINO)BUTANAMIDE'>5I1</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5acb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5acb OCA], [https://pdbe.org/5acb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5acb RCSB], [https://www.ebi.ac.uk/pdbsum/5acb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5acb ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5acb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5acb OCA], [http://pdbe.org/5acb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5acb RCSB], [http://www.ebi.ac.uk/pdbsum/5acb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5acb ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref>
[https://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Bullock, A]]
[[Category: Bullock A]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown N]]
[[Category: Carpenter, E P]]
[[Category: Carpenter EP]]
[[Category: Chalk, R]]
[[Category: Chalk R]]
[[Category: Clarke, S E.Dixon]]
[[Category: Dixon Clarke SE]]
[[Category: Delft, F von]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Elkins JM]]
[[Category: Elkins, J M]]
[[Category: Fitzpatrick F]]
[[Category: Fitzpatrick, F]]
[[Category: Goubin S]]
[[Category: Goubin, S]]
[[Category: Kopec J]]
[[Category: Kopec, J]]
[[Category: Mackenzie A]]
[[Category: Mackenzie, A]]
[[Category: Mahajan P]]
[[Category: Mahajan, P]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Strain-Damerell C]]
[[Category: Strain-Damerell, C]]
[[Category: Tallant C]]
[[Category: Tallant, C]]
[[Category: Wiggers H]]
[[Category: Wiggers, H]]
[[Category: Von Delft F]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5acb"