5ajn: Difference between revisions

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<StructureSection load='5ajn' size='340' side='right'caption='[[5ajn]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
<StructureSection load='5ajn' size='340' side='right'caption='[[5ajn]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ajn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJN FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ajn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AJN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ajo|5ajo]], [[5ajp|5ajp]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ajn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajn OCA], [https://pdbe.org/5ajn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ajn RCSB], [https://www.ebi.ac.uk/pdbsum/5ajn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajn ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polypeptide_N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.41 2.4.1.41] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajn OCA], [http://pdbe.org/5ajn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ajn RCSB], [http://www.ebi.ac.uk/pdbsum/5ajn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ajn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>
[https://www.uniprot.org/uniprot/MUC5A_HUMAN MUC5A_HUMAN] Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).<ref>PMID:14535999</ref> <ref>PMID:14535999</ref> <ref>PMID:14718370</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Polypeptide N-acetylgalactosaminyltransferase]]
[[Category: Bernado P]]
[[Category: Bernado, P]]
[[Category: Bernardes GJL]]
[[Category: Bernardes, G J.L]]
[[Category: Bruscolini P]]
[[Category: Bruscolini, P]]
[[Category: Clausen H]]
[[Category: Clausen, H]]
[[Category: Companon I]]
[[Category: Companon, I]]
[[Category: Corzana F]]
[[Category: Corzana, F]]
[[Category: Hurtado-Guerrero R]]
[[Category: Hurtado-Guerrero, R]]
[[Category: Iglesias-Fernandez J]]
[[Category: Iglesias-Fernandez, J]]
[[Category: Kong Y]]
[[Category: Kong, Y]]
[[Category: Lira-Navarrete E]]
[[Category: Lira-Navarrete, E]]
[[Category: Lostao A]]
[[Category: Lostao, A]]
[[Category: Pallares MC]]
[[Category: Pallares, M C]]
[[Category: Peregrina JM]]
[[Category: Peregrina, J M]]
[[Category: Rovira C]]
[[Category: Rovira, C]]
[[Category: DelasRivas M]]
[[Category: DelasRivas, M]]
[[Category: Active form]]
[[Category: Afm]]
[[Category: Coarse-grained model]]
[[Category: Compact form]]
[[Category: Extended form]]
[[Category: Glycopeptide]]
[[Category: Inactive form]]
[[Category: Lectin domain]]
[[Category: Sax]]
[[Category: Transferase]]
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