5qqz: Difference between revisions

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'''Unreleased structure'''


The entry 5qqz is ON HOLD
==PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1675346324==
 
<StructureSection load='5qqz' size='340' side='right'caption='[[5qqz]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
Authors: Bezerra, G.A., Foster, W., Bailey, H., Shrestha, L., Krojer, T., Talon, R., Brandao-Neto, J., Douangamath, A., Nicola, B.B., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Brennan, P.E., Yue, W.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5qqz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QQZ FirstGlance]. <br>
Description: PanDDA analysis group deposition --Crystal Structure of human ALAS2A in complex with Z1675346324
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NUJ:trans-3-[(2,6-dimethylpyrimidin-4-yl)(methyl)amino]cyclobutan-1-ol'>NUJ</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
[[Category: Foster, W]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qqz OCA], [http://pdbe.org/5qqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qqz RCSB], [http://www.ebi.ac.uk/pdbsum/5qqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qqz ProSAT]</span></td></tr>
[[Category: Arrowsmith, C.H]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: 5-aminolevulinate synthase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Bailey, H]]
[[Category: Bezerra, G A]]
[[Category: Bountra, C]]
[[Category: Brandao-Neto, J]]
[[Category: Brandao-Neto, J]]
[[Category: Talon, R]]
[[Category: Brennan, P E]]
[[Category: Brennan, P.E]]
[[Category: Delft, F von]]
[[Category: Shrestha, L]]
[[Category: Douangamath, A]]
[[Category: Bezerra, G.A]]
[[Category: Edwards, A]]
[[Category: Edwards, A]]
[[Category: Nicola, B.B]]
[[Category: Foster, W]]
[[Category: Douangamath, A]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: Yue, W.W]]
[[Category: Nicola, B B]]
[[Category: Von Delft, F]]
[[Category: Shrestha, L]]
[[Category: Bailey, H]]
[[Category: Talon, R]]
[[Category: Bountra, C]]
[[Category: Yue, W W]]
[[Category: Pandda]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Transferase]]
[[Category: Xchemexplorer]]
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