2v5o: Difference between revisions

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[[Image:2v5o.jpg|left|200px]]
{{Seed}}
[[Image:2v5o.png|left|200px]]


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{{STRUCTURE_2v5o|  PDB=2v5o  |  SCENE=  }}  
{{STRUCTURE_2v5o|  PDB=2v5o  |  SCENE=  }}  


'''STRUCTURE OF HUMAN IGF2R DOMAINS 11-14'''
===STRUCTURE OF HUMAN IGF2R DOMAINS 11-14===




==Overview==
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Embryonic development and normal growth require exquisite control of insulin-like growth factors (IGFs). In mammals the extracellular region of the cation-independent mannose-6-phosphate receptor has gained an IGF-II-binding function and is termed type II IGF receptor (IGF2R). IGF2R sequesters IGF-II; imbalances occur in cancers and IGF2R is implicated in tumour suppression. We report crystal structures of IGF2R domains 11-12, 11-12-13-14 and domains 11-12-13/IGF-II complex. A distinctive juxtaposition of these domains provides the IGF-II-binding unit, with domain 11 directly interacting with IGF-II and domain 13 modulating binding site flexibility. Our complex shows that Phe19 and Leu53 of IGF-II lock into a hydrophobic pocket unique to domain 11 of mammalian IGF2Rs. Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site.
The line below this paragraph, {{ABSTRACT_PUBMED_18046459}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18046459 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18046459}}


==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:30:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:46:28 2008''

Revision as of 14:46, 27 July 2008

File:2v5o.png

Template:STRUCTURE 2v5o

STRUCTURE OF HUMAN IGF2R DOMAINS 11-14

Template:ABSTRACT PUBMED 18046459

About this Structure

2V5O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and functional analysis of the IGF-II/IGF2R interaction., Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY, EMBO J. 2008 Jan 9;27(1):265-76. Epub 2007 Nov 29. PMID:18046459

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