6s4n: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6s4n is ~~ON HOLD~~

==LXRbeta ligand binding domain in comlpex with small molecule inhibitors==

~~Authors~~: ~~Sandmark~~, J., ~~Jansson~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[6s4n]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S4N FirstGlance]. <br>

~~Description~~: ~~LXRbeta ligand binding domain in comlpex with small molecule inhibitors~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KUW:2-[5-chloranyl-6-[4-[[1,1,3-tris(oxidanylidene)-5-phenyl-2-propan-2-yl-1,2-thiazol-4-yl]amino]piperidin-1-yl]pyridin-3-yl]ethanoic+acid'>KUW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4n OCA], [http://pdbe.org/6s4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s4n RCSB], [http://www.ebi.ac.uk/pdbsum/6s4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4n ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Jansson, A]]

[[Category: Sandmark, J]]

[[Category: Liver x receptor beta]]

[[Category: Lxr beta]]

[[Category: Lxrb]]

[[Category: Nuclear hormone receptor]]

[[Category: Nuclear protein]]

[[Category: Receptor ligand binding domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6s4n is ON HOLD
+==LXRbeta ligand binding domain in comlpex with small molecule inhibitors==
+<StructureSection load='6s4n' size='340' side='right'caption='[[6s4n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Sandmark, J., Jansson, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6s4n]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S4N FirstGlance]. <br>
-Description: LXRbeta ligand binding domain in comlpex with small molecule inhibitors
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KUW:2-[5-chloranyl-6-[4-[[1,1,3-tris(oxidanylidene)-5-phenyl-2-propan-2-yl-1,2-thiazol-4-yl]amino]piperidin-1-yl]pyridin-3-yl]ethanoic+acid'>KUW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4n OCA], [http://pdbe.org/6s4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s4n RCSB], [http://www.ebi.ac.uk/pdbsum/6s4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4n ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Jansson, A]]
 [[Category: Sandmark, J]]
+[[Category: Liver x receptor beta]]
+[[Category: Lxr beta]]
+[[Category: Lxrb]]
+[[Category: Nuclear hormone receptor]]
+[[Category: Nuclear protein]]
+[[Category: Receptor ligand binding domain]]