6s5t: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Legionella pneumophila SidJ-Human calmodulin complex== | |||
<StructureSection load='6s5t' size='340' side='right'caption='[[6s5t]], [[Resolution|resolution]] 4.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6s5t]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S5T FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5t OCA], [http://pdbe.org/6s5t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s5t RCSB], [http://www.ebi.ac.uk/pdbsum/6s5t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5t ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/CALM2_HUMAN CALM2_HUMAN]] Catecholaminergic polymorphic ventricular tachycardia;Brugada syndrome;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM2 are the cause of LQT15. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CALM2_HUMAN CALM2_HUMAN]] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Adams, M]] | [[Category: Adams, M]] | ||
[[Category: Bhogaraju, S]] | [[Category: Bhogaraju, S]] | ||
[[Category: Galej, W P]] | |||
[[Category: Pfleiderer, M M]] | |||
[[Category: Bacterial glutamylase]] | |||
[[Category: Calmodulin-dependent]] | |||
[[Category: Legionella]] | |||
[[Category: Pseudo kinase]] | |||
[[Category: Sdea]] | |||
[[Category: Serine ubiquitination]] | |||
[[Category: Sidj]] | |||
[[Category: Transferase]] | |||
Revision as of 06:30, 24 July 2019
Legionella pneumophila SidJ-Human calmodulin complex
| ||||||||||||
