3lrq: Difference between revisions
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<StructureSection load='3lrq' size='340' side='right'caption='[[3lrq]], [[Resolution|resolution]] 2.29Å' scene=''> | <StructureSection load='3lrq' size='340' side='right'caption='[[3lrq]], [[Resolution|resolution]] 2.29Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3lrq]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3lrq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LRQ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.292Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lrq OCA], [https://pdbe.org/3lrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lrq RCSB], [https://www.ebi.ac.uk/pdbsum/3lrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lrq ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/TRI37_HUMAN TRI37_HUMAN] Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:[https://omim.org/entry/253250 253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.<ref>PMID:15885686</ref> <ref>PMID:10888877</ref> <ref>PMID:12754710</ref> <ref>PMID:15108285</ref> <ref>PMID:17100991</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TRI37_HUMAN TRI37_HUMAN] E3 ubiquitin-protein ligase.<ref>PMID:15885686</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/3lrq_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/3lrq_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| Line 27: | Line 26: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Acton | [[Category: Acton TB]] | ||
[[Category: Chen | [[Category: Chen Y]] | ||
[[Category: Ciccosanti | [[Category: Ciccosanti C]] | ||
[[Category: Everett | [[Category: Everett JK]] | ||
[[Category: Hunt | [[Category: Hunt JF]] | ||
[[Category: Kuzin | [[Category: Kuzin A]] | ||
[[Category: Mao | [[Category: Mao M]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Nair R]] | |||
[[Category: Nair | [[Category: Rost B]] | ||
[[Category: Rost | [[Category: Seetharaman J]] | ||
[[Category: Seetharaman | [[Category: Shastry R]] | ||
[[Category: Shastry | [[Category: Tong L]] | ||
[[Category: Tong | [[Category: Xiao R]] | ||
[[Category: Xiao | |||
