1ytb: Difference between revisions

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[[Image:1ytb.~~jpg~~|left|200px]]

[[Image:1ytb.png|left|200px]]

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~~==Overview==~~

The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA.

==About this Structure==

1YTB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1YTB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YTB OCA].

~~==Reference==~~

~~Crystal structure of a yeast TBP/TATA-box complex., Kim Y, Geiger JH, Hahn S, Sigler PB, Nature. 1993 Oct 7;365(6446):512-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8413604 8413604]~~

[[Category: Saccharomyces cerevisiae]]

[[Category: Single protein]]

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[[Category: Sigler, P B.]]

[[Category: Protein-dna complex]]

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-[[Image:1ytb.jpg|left|200px]]
+[[Image:1ytb.png|left|200px]]
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-==Overview==
+{{ABSTRACT_8413604}}
-The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA.
 ==About this Structure==
 YTB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. The following page contains interesting information on the relation of 1YTB with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YTB OCA].
-==Reference==
-Crystal structure of a yeast TBP/TATA-box complex., Kim Y, Geiger JH, Hahn S, Sigler PB, Nature. 1993 Oct 7;365(6446):512-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8413604 8413604]
 [[Category: Saccharomyces cerevisiae]]
 [[Category: Single protein]]
@@ Line 28: / Line 24: @@
 [[Category: Sigler, P B.]]
 [[Category: Protein-dna complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:39:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:09:04 2008''