1tgh: Difference between revisions

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[[Image:1tgh.gif|left|200px]]
[[Image:1tgh.png|left|200px]]


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==Overview==
{{ABSTRACT_8757291}}
The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.


==Disease==
==Disease==
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==About this Structure==
==About this Structure==
1TGH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGH OCA].  
1TGH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1TGH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb67_1.html TATA-Binding Protein]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGH OCA].  
==Reference==
How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8757291 8757291]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:39:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:00:43 2008''

Revision as of 15:00, 26 June 2008

File:1tgh.png

Template:STRUCTURE 1tgh

TATA BINDING PROTEIN (TBP)/DNA COMPLEX


Template:ABSTRACT 8757291

Disease

Known disease associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]

About this Structure

1TGH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1TGH with [TATA-Binding Protein]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:00:43 2008

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