Rapamycin: Difference between revisions
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New page: '''Rapamycin''' is an immuno-suppressant and anticancer drug. It acts by binding the the mTORC1 protein complex, a kinase that regulates cell growth and metabolism. In the future, it might... |
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'''Rapamycin''' is an immuno-suppressant and anticancer drug. It acts by binding the the mTORC1 protein complex, a kinase that regulates cell growth and metabolism. In the future, it might also be used in treatment of type 2 [[diabetes]]<ref>https://doi.org/10.3389/fphar.2016.00395</ref>. | '''Rapamycin''', isolated from the bacterium ''Streptomyces hygroscopicus'', is an immuno-suppressant and anticancer drug<ref>https://en.wikipedia.org/wiki/Sirolimus</ref>. It acts by binding the the mTORC1 protein complex, a kinase that regulates cell growth and metabolism. In the future, it might also be used in treatment of type 2 [[diabetes]]<ref>https://doi.org/10.3389/fphar.2016.00395</ref>. | ||
==Structure== | ==Structure== | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
[[Image:Rapamycin.png]] | |||
<ref>PMID: 23358420</ref> | Rapamycin, a macrolide, has a <scene name='82/821566/Rapamycin/1'>cyclic structure</scene>. It <scene name='82/821566/Rapamycin/2'>binds to the regulator protein mTORC1</scene> with the help of another protein called FKBP52<ref>PMID: 23358420</ref> | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 14:25, 17 July 2019
Rapamycin, isolated from the bacterium Streptomyces hygroscopicus, is an immuno-suppressant and anticancer drug[1]. It acts by binding the the mTORC1 protein complex, a kinase that regulates cell growth and metabolism. In the future, it might also be used in treatment of type 2 diabetes[2].
Structure
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