Nitroreductase: Difference between revisions
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== Function == | == Function == | ||
'''Nitroreductase''' (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO<sub>2</sub> group. The NO<sub>2</sub> group is reduced to hydroxylamine<ref>PMID:11491290</ref>. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. | '''Nitroreductase''' or '''oxygen-insensitive NAD(P)H nitroreductase''' (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO<sub>2</sub> group. The NO<sub>2</sub> group is reduced to hydroxylamine<ref>PMID:11491290</ref>. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. | ||
== Relevance == | == Relevance == | ||
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*Nitroreductase | *Nitroreductase | ||
**[[1f5v ]], [[1oo5]] – EcNR – ''Escherichia coli''<br /> | **[[1f5v ]], [[1oo5]] – EcNR + FMN – ''Escherichia coli''<br /> | ||
**[[3x21]], [[3x22]] – EcNR (mutant)<br /> | **[[3x21]], [[3x22]] – EcNR (mutant) + FMN<br /> | ||
**[[3bm1]], [[1ds7]] – EcNR minimal<br /> | **[[3bm1]], [[1ds7]] – EcNR minimal + FMN<br /> | ||
**[[3bm2]] – EcNR minimal -FMN<br /> | **[[3bm2]] – EcNR minimal -FMN<br /> | ||
**[[1nec]], [[1kqd]] – EclNR – ''Enterobacter cloacae''<br /> | **[[1nec]], [[1kqd]] – EclNR + FMN – ''Enterobacter cloacae''<br /> | ||
**[[1ywq]], [[2i7h]] – NR – ''Bacillus cereus''<br /> | **[[1ywq]], [[2i7h]] – NR + FMN – ''Bacillus cereus''<br /> | ||
**[[5hdj]] – NR – ''Bacillus megaterium''<br /> | **[[5hdj]] – NR + FMN – ''Bacillus megaterium''<br /> | ||
**[[2b67]] – NR – ''Streptococcus pneumonia''<br /> | **[[2b67]] – NR + FMN – ''Streptococcus pneumonia''<br /> | ||
**[[3ek3]], [[3hoi]] – NR – ''Bacterioides fragilis''<br /> | **[[3ek3]], [[3hoi]] – NR + FMN – ''Bacterioides fragilis''<br /> | ||
**[[3g14]] – NR – ''Clostridium novyi''<br /> | **[[3g14]] – NR – ''Clostridium novyi''<br /> | ||
**[[3h4o]], [[3koq]] - NR – ''Clostridium difficile''<br /> | **[[3h4o]], [[3koq]] - NR + FMN – ''Clostridium difficile''<br /> | ||
**[[3gr3]] – NR – ''Bartonella henselae''<br /> | **[[3gr3]] – NR + FMN – ''Bartonella henselae''<br /> | ||
**[[3hzn]] – NR – ''Salmonella typhimurium''<br /> | **[[3hzn]] – NR – ''Salmonella typhimurium''<br /> | ||
**[[3k6h]] – NR – ''Agrobacterium tumefaciens''<br /> | **[[3k6h]] – NR + FMN – ''Agrobacterium tumefaciens''<br /> | ||
**[[2wzv]], [[2ymv]] – MsNR – ''Mycobacterium smegmatis''<br /> | **[[2wzv]], [[2ymv]] – MsNR + FMN – ''Mycobacterium smegmatis''<br /> | ||
**[[3of4]] – NR FMN | **[[3of4]] – NR + FMN + FAD – ''Idiomarina loihiensis''<br /> | ||
**[[3n2s]] – NR – ''Bacillus subtilis''<br /> | **[[3n2s]] – NR + FMN – ''Bacillus subtilis''<br /> | ||
**[[3pxv]] – NR – ''Desulfitobacterium hafniense''<br /> | **[[3pxv]] – NR + FMN – ''Desulfitobacterium hafniense''<br /> | ||
**[[3qdl]] – NR – ''Helicobacter pylori''<br /> | **[[3qdl]] – NR + FMN – ''Helicobacter pylori''<br /> | ||
**[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br /> | **[[3r5l]], [[3r5p]] - MtNR – ''Mycobacterium tuberculosis''<br /> | ||
**[[ | **[[3ge6]] – NR + FMN – ''Exiguobacterium sibiricum''<br /> | ||
**[[ | **[[4dn2]] – NR + FMN – ''Geobacter metallireducens''<br /> | ||
**[[ | **[[5ko7]], [[5ko8]], [[5krd]] – NR + FMN – ''Haliscomenobacter hydrossis''<br /> | ||
**[[ | **[[7dp0]] – SpNR + FMN – ''Sphingopyxis''<br /> | ||
**[[7dp1]], [[7dp2]] – SpNR (mutant) + FMN <br /> | |||
**[[6czp]] – NR + FMN – ''Vibrio vulnificus''<br /> | |||
*Copper-induced nitroreductase | *Copper-induced nitroreductase | ||
**[[2wqf]] – LlNR – ''Lactococcus lactis''<br /> | **[[2wqf]] – LlNR + FMN – ''Lactococcus lactis''<br /> | ||
**[[4bn6]] – LlNR + chloramphenicol<br /> | **[[4bn6]] – LlNR + FMN + chloramphenicol<br /> | ||
**[[4bn7]], [[4bn8]] – LlNR + phenol derivative<br /> | **[[4bn7]], [[4bn8]] – LlNR + FMN + phenol derivative<br /> | ||
**[[4bn9]] – LlNR + nicotinic acid<br /> | **[[4bn9]] – LlNR + FMN + nicotinic acid<br /> | ||
**[[4bnb]] – LlNR + nitroquinoline<br /> | **[[4bnb]] – LlNR + FMN + nitroquinoline<br /> | ||
*Nitrobenzoate nitroreductase | *Nitrobenzoate nitroreductase | ||
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**[[4z85]] – NR – ''Psudomonas fluorescens''<br /> | **[[4z85]] – NR – ''Psudomonas fluorescens''<br /> | ||
*Nitroreductase | *Nitroreductase complex | ||
**[[1kqb]], [[5j8g]]– EclNR + benzoate derivative<br /> | **[[1kqb]], [[5j8g]]– EclNR + FMN + benzoate derivative<br /> | ||
**[[1kqc]] – EclNR + acetate<br /> | **[[1kqc]] – EclNR + FMN + acetate<br /> | ||
**[[1ylr]], [[1ylu]] - EcNR + acetate<br /> | **[[1ylr]], [[1ylu]] - EcNR + FMN + acetate<br /> | ||
**[[1icr]], [[1icu]], [[1icv]], [[5j8d]] – EcNR + NAD derivative<br /> | **[[1icr]], [[1icu]], [[1icv]], [[5j8d]] – EcNR + FMN + NAD derivative<br /> | ||
**[[1ooq]] – EcNR + dicoumarol<br /> | **[[1ooq]] – EcNR + FMN + dicoumarol<br /> | ||
**[[1oo6]], [[1oon]], [[1idt]] – EcNR + benzamide derivative<br /> | **[[1oo6]], [[1oon]], [[1idt]] – EcNR + FMN + benzamide derivative<br /> | ||
**[[1yki]] – EcNR + antibiotic<br /> | **[[1yki]] – EcNR + FMN + antibiotic<br /> | ||
**[[2wzw]] - MsNR + NADPH<br /> | **[[7nb9]] – EcNR + FMN + nitrofurantoin<br /> | ||
**[[7nmp]], [[7nnx]] – EcNR + FMN + quinone derivative<br /> | |||
**[[7niy]] – EcNR (mutant) + FMN + imidazole<br /> | |||
**[[2wzw]] - MsNR + FMN + NADPH<br /> | |||
**[[6czp]] – NR + FMN – ''Vibrio vulnificus''<br /> | **[[6czp]] – NR + FMN – ''Vibrio vulnificus''<br /> | ||
**[[3r5r]], [[3r5w]] – MtNR F420<br /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:06, 24 November 2021
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3D structures of nitroreductase
Updated on 24-November-2021
