2rfh: Difference between revisions

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[[Image:2rfh.jpg|left|200px]]
{{Seed}}
[[Image:2rfh.png|left|200px]]


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{{STRUCTURE_2rfh|  PDB=2rfh  |  SCENE=  }}  
{{STRUCTURE_2rfh|  PDB=2rfh  |  SCENE=  }}  


'''Crystal Structure Analysis of CPA-2-benzyl-3-nitropropanoic acid complex'''
===Crystal Structure Analysis of CPA-2-benzyl-3-nitropropanoic acid complex===




==Overview==
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2-Substituted 3-nitropropanoic acids were designed and synthesized as inhibitors against carboxypeptidase A (CPA). (R)-2-Benzyl- 3-nitropropanoic acid showed a potent inhibition against CPA (K(i)=0.15 microM). X-ray crystallography discloses that the nitro group well mimics the transition state occurred in the hydrolysis catalyzed by CPA, that is, an O,O'-bidentate coordination to the zinc ion and the two respective hydrogen bonds with Glu-270 and Arg-127. Because the nitro group is a planar species, we proposed (R)-2-benzyl-3-nitropropanoic acid as a pseudo-transition-state analog inhibitor against CPA.
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==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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