2z90: Difference between revisions

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{{STRUCTURE_2z90|  PDB=2z90  |  SCENE=  }}  
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'''Crystal Structure of the Second Dps from Mycobacterium smegmatis'''
===Crystal Structure of the Second Dps from Mycobacterium smegmatis===




==Overview==
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A second DNA binding protein from stationary-phase cells of Mycobacterium smegmatis (MsDps2) has been identified from the bacterial genome. It was cloned, expressed and characterised and its crystal structure was determined. The core dodecameric structure of MsDps2 is the same as that of the Dps from the organism described earlier (MsDps1). However, MsDps2 possesses a long N-terminal tail instead of the C-terminal tail in MsDps1. This tail appears to be involved in DNA binding. It is also intimately involved in stabilizing the dodecamer. Partly on account of this factor, MsDps2 assembles straightway into the dodecamer, while MsDps1 does so on incubation after going through an intermediate trimeric stage. The ferroxidation centre is similar in the two proteins, while the pores leading to it exhibit some difference. The mode of sequestration of DNA in the crystalline array of molecules, as evidenced by the crystal structures, appears to be different in MsDps1 and MsDps2, highlighting the variability in the mode of Dps-DNA complexation. A sequence search led to the identification of 300 Dps molecules in bacteria with known genome sequences. Fifty bacteria contain two or more types of Dps molecules each, while 195 contain only one type. Some bacteria, notably some pathogenic ones, do not contain Dps. A sequence signature for Dps could also be derived from the analysis.
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==About this Structure==
==About this Structure==
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[[Category: Ferroxidation]]
[[Category: Ferroxidation]]
[[Category: Quarternary assembly]]
[[Category: Quarternary assembly]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:44:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:20:36 2008''

Revision as of 23:20, 27 July 2008

File:2z90.png

Template:STRUCTURE 2z90

Crystal Structure of the Second Dps from Mycobacterium smegmatis

Template:ABSTRACT PUBMED 18061613

About this Structure

2Z90 is a Single protein structure of sequence from Mycobacterium smegmatis. Full crystallographic information is available from OCA.

Reference

Structural studies on the second Mycobacterium smegmatis Dps: invariant and variable features of structure, assembly and function., Roy S, Saraswathi R, Chatterji D, Vijayan M, J Mol Biol. 2008 Jan 25;375(4):948-59. Epub 2007 Oct 16. PMID:18061613

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