6pk7: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6pk7 is ~~ON HOLD~~ ~~until Paper Publication~~

==cryoEM structure of the product-bound human CTP synthase 2 filament==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6pk7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PK7 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PK7 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/CTP_synthase_(glutamine_hydrolyzing) CTP synthase (glutamine hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pk7 OCA], [http://pdbe.org/6pk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pk7 RCSB], [http://www.ebi.ac.uk/pdbsum/6pk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pk7 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PYRG2_HUMAN PYRG2_HUMAN]] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.<ref>PMID:10899599</ref> <ref>PMID:16179339</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Kollman, J M]]

[[Category: Lynch, E M]]

[[Category: Enzyme]]

[[Category: Filament]]

[[Category: Protein fibril]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6pk7 is ON HOLD  until Paper Publication
+==cryoEM structure of the product-bound human CTP synthase 2 filament==
+<StructureSection load='6pk7' size='340' side='right'caption='[[6pk7]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6pk7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PK7 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase_(glutamine_hydrolyzing) CTP synthase (glutamine hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pk7 OCA], [http://pdbe.org/6pk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pk7 RCSB], [http://www.ebi.ac.uk/pdbsum/6pk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pk7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PYRG2_HUMAN PYRG2_HUMAN]] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.<ref>PMID:10899599</ref> <ref>PMID:16179339</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Kollman, J M]]
+[[Category: Lynch, E M]]
+[[Category: Enzyme]]
+[[Category: Filament]]
+[[Category: Protein fibril]]