6pwf: Difference between revisions
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==Cryo-EM structure of the ATPase domain of chromatin remodeling factor ISWI bound to the nucleosome== | |||
<StructureSection load='6pwf' size='340' side='right'caption='[[6pwf]], [[Resolution|resolution]] 4.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6pwf]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PWF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PWF FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pwf OCA], [http://pdbe.org/6pwf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pwf RCSB], [http://www.ebi.ac.uk/pdbsum/6pwf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pwf ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A0B4KFZ9_DROME A0A0B4KFZ9_DROME]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.[RuleBase:RU000528][SAAS:SAAS00581158] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Chittori, S]] | |||
[[Category: Subramaniam, S]] | |||
[[Category: Atp-dependent chromatin remodeler]] | |||
[[Category: Dna-binding protein]] | |||
[[Category: Iswi]] | |||
[[Category: Nucleosome]] | |||
[[Category: Structural protein-dna complex]] | |||
Revision as of 06:06, 21 August 2019
Cryo-EM structure of the ATPase domain of chromatin remodeling factor ISWI bound to the nucleosome
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