Peroxiredoxin

spinqualitylabelsall models Typical 2-cys peroxiredoxin dimer complex with Cl- ions 1qq2 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Peroxiredoxin (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid hyper oxide forming a Cys-SOH intermediate. A second Cys residue resolves the intermediate to a protein disulfide bond. The Prxs are divided into 3 types according to their intermediate resolving mechanism: typical 2-Cysteine Prx in which the Cys-Cys bond is formed between two subunits, atypical 2-Cys Prx in which the bond is formed within one subunit and 1-Cysteine Prx which uses a single Cys residue for the catalysis. Typical 2-Cys Prx Prx 1 interacts with signaling molecules. Prx 2 is essential for sustaining erythrocyte life span. Prx 3 is mitochondria-specific.. Prx 4 localizes to the cytoplasm and regulates the activation of NF-κB. Atypical 2-Cys Prx Prx 5 protects from mitochondrial DNA damage induced by H2O2. 1-Cys Prx Prx 6 reduces peroxidized membrane phospholipids. Relevance Prx are over expressed in cancer tissue. Prx 4 mediates osteoclast activation in cancer cells. Structural highlights In the typical 2-cysteine Prx the Cys-Cys bond is formed between two subunits. Cl coordination site. Water molecules is shown as red sphere. 3D Structures of Peroxiredoxin Peroxiredoxin 3D structures

3D Structures of Peroxiredoxin

Updated on 14-November-2019

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• Peroxiredoxin
  • Peroxiredoxin 3D structures - h2Cys-Prx – human
    
  • 1qq2 – r2Cys-Prx – rat
    
  • 2a4v – yPrx dot5 C-terminal (mutant) – yeast
    
  • 3cmi – yPrx hyr1 - yeast
    
  • 5ept - yPrx tsa2
    
  • 3sbc – yPrx tsa1 (mutant)
    
  • 5dvb - yPrx tsa2 (mutant)
    
  • 4g2e – Prx – Sulfolobus tokodaii
    
  • 6q5v – Prx – Sulfolobus islandicus
    
  • 5xbr – PhPrx – Pyrococcus horikoshii
    
  • 5xbq – PhPrx (mutant)
    
  • 4llr - 2Cys-Prx – Trypanosoma cruzi
    
  • 1we0 – Prx – Amphibacillus xylanus
    
  • 2cv4, 2cx3, 2cx4 – ApPrx – Aeropyrum pernix
    
  • 5xbs – ApPrx (mutant)
    
  • 3drn – SsPrx – Sulfolobus solfataricus
    
  • 3hjp – SsPrx (mutant)
    
  • 3ixr – Prx PRXQ (mutant) – Xylella fastidiosa
    
  • 5epf - Prx – Mycobacterium tuberculosis
    
  • 2c0d – Pf2Cys-Prx – Plasmodium falciparum
    
  • 1xiy – Pf1Cys-Prx
    
  • 1xcc, 2h01, 3tb2 - 1Cys-Prx – Plasmodium yoelii
    
  • 2i81 - 2Cys-Prx – Plasmodium vivax
    
  • 6itz - TkPrx – Thermococcus kodakarensis
    
  • 6iu0, 6iu1 – TkPrx (mutant)
    
  • 6e0f, 6e0g – 2Cys-Prx – Leishmania infantum
    
  • 5zte – 2Cys-Prx (mutant) – Arabidopsis thaliana
    
  • 5ovq - Prx – Aquifex aeolicus
    
• Peroxiredoxin 1
  • 4xcs - hPrx 1 (mutant)
    
  • 2rii, 3hy2 – hPrx 1 (mutant)+sulfiredoxin 1
    
  • 2z9s – rPrx 1 (mutant)
    
  • 3zl5 - mPrx 1 (mutant) – mouse
    
  • 5ykj – y1Cys-Prx
    
  • 4kw6, 4fh8 – Prx 1 – Ancylostoma ceylanicum
    
• Peroxiredoxin 2
  • 5ijt – hPrx II
    
  • 2pwj – Prx II – garden pea
    
  • 4dsq, 4dsr, 4h86, 4owy – yPrx II
    
  • 4dss – yPrx II (mutant) + thioredoxin II
    
  • 1tp9 – Prx II – Populus trichocarpa
    
• Peroxiredoxin 3
  • 1zye – Prx III (mutant) – bovine
    
  • 5ykw - yPrx III (mutant) + peptide
    
  • 5k1g, 5k2i - VvPrx III (mutant) – Vibrio vulnificus
    
  • 5k2j - VvPrx III (mutant) + H2O2
    
• Peroxiredoxin 4
  • 3tjf, 3tjg, 3tjj, 3tjk, 3tkr - hPrx 4 (mutant)
    
  • 5hqp - hPrx 4 (mutant) + ERP44
    
  • 4rqx – hPrx 4 + thioethanesulfonic acid
    
  • 2pn8, 3tjb, 3tkp, 3tkq, 3tks – hPrx 4
    
  • 3vwu, 3vwv - mPrx 4 (mutant)
    
  • 3qpm – Prx 4 – Larimichtys crocea
    
• Peroxiredoxin 5
  • 1urm – hPrx 5 (mutant) – human
    
  • 2vl2, 2vl3, 2vl9, 1h4o, 1hd2, 1oc3 – hPrx 5
    
  • 3mng – hPrx 5+DTT
    
  • 4k7i, 4k7n, 4k7o, 4mmm – hPrx 5 catalytic domain + fragment
    
  • 2wfc – lPrx 5 - lugworm
    
  • 2xhf – Prx 5 – Alvinella pompejana
    
• Peroxiredoxin 6
  • 5b6m, 5b6n - hPrx 6
    
  • 2v2g – lPrx 6
    
  • 2v32, 2v41 – lPrx 6 (mutant)
    
• Peroxiredoxin Asp F3
  • 5j9b – NfPrx – Neosartorya fumigata
    
  • 5j9c - NfPrx (mutant)
    

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