6seg: Difference between revisions
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==Class1: CENP-A nucleosome in complex with CENP-C central region== | |||
<StructureSection load='6seg' size='340' side='right'caption='[[6seg]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6seg]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SEG FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6seg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6seg OCA], [http://pdbe.org/6seg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6seg RCSB], [http://www.ebi.ac.uk/pdbsum/6seg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6seg ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Ali-Ahmad, A]] | |||
[[Category: Bilokapic, S]] | |||
[[Category: Halic, M]] | |||
[[Category: Schafer, I B]] | |||
[[Category: Sekulic, N]] | |||
[[Category: Cenp-a]] | |||
[[Category: Centromere]] | |||
[[Category: Centromeric chromatin]] | |||
[[Category: Nuclear protein]] | |||
[[Category: Nucleosome]] | |||
Revision as of 16:50, 14 August 2019
Class1: CENP-A nucleosome in complex with CENP-C central region
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