5qqu: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
No edit summary
OCA (talk | contribs)
No edit summary
 
Line 3: Line 3:
<StructureSection load='5qqu' size='340' side='right'caption='[[5qqu]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='5qqu' size='340' side='right'caption='[[5qqu]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5qqu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QQU FirstGlance]. <br>
<table><tr><td colspan='2'>[[5qqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QQU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NTG:5-(1,4-oxazepan-4-yl)pyridine-2-carbonitrile'>NTG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-aminolevulinate_synthase 5-aminolevulinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.37 2.3.1.37] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NTG:5-(1,4-oxazepan-4-yl)pyridine-2-carbonitrile'>NTG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qqu OCA], [http://pdbe.org/5qqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qqu RCSB], [http://www.ebi.ac.uk/pdbsum/5qqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qqu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qqu OCA], [https://pdbe.org/5qqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qqu RCSB], [https://www.ebi.ac.uk/pdbsum/5qqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qqu ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>
[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN] X-linked sideroblastic anemia;Erythropoietic protoporphyria. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. Gain of function mutations in ALS2 are responsible for XLDPT, but they can also be a possible aggravating factor in congenital erythropoietic porphyria and other erythropoietic disorders caused by mutations in other genes (PubMed:21309041).<ref>PMID:21309041</ref>  
== Function ==
[https://www.uniprot.org/uniprot/HEM0_HUMAN HEM0_HUMAN]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 5-aminolevulinate synthase]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bailey, H]]
[[Category: Bailey H]]
[[Category: Bezerra, G A]]
[[Category: Bezerra GA]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Brandao-Neto, J]]
[[Category: Brandao-Neto J]]
[[Category: Brennan, P E]]
[[Category: Brennan PE]]
[[Category: Delft, F von]]
[[Category: Douangamath A]]
[[Category: Douangamath, A]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Foster W]]
[[Category: Foster, W]]
[[Category: Krojer T]]
[[Category: Krojer, T]]
[[Category: Nicola BB]]
[[Category: Nicola, B B]]
[[Category: Shrestha L]]
[[Category: Shrestha, L]]
[[Category: Talon R]]
[[Category: Talon, R]]
[[Category: Yue WW]]
[[Category: Yue, W W]]
[[Category: Von Delft F]]
[[Category: Pandda]]
[[Category: Sgc - diamond i04-1 fragment screening]]
[[Category: Transferase]]
[[Category: Xchemexplorer]]