3c0t: Difference between revisions

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[[Image:3c0t.png|left|200px]]

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~~'''~~Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18~~'''~~

===Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18===

~~==Overview==~~

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~~A combination of crystallography~~, ~~biochemistry~~, ~~and gene expression analysis identifies~~ the ~~coactivator subcomplex Med8C/18~~/~~20 as a functionally distinct submodule of the Mediator head module. Med8C forms a conserved alpha-helix that tethers Med18~~/~~20 to the Mediator~~. ~~Deletion of Med8C in vivo results in dissociation of Med18/20 from Mediator and in loss of transcription activity of extracts~~. ~~Deletion of med8C~~, ~~med18, or med20 causes similar changes in~~ the ~~yeast transcriptome, establishing Med8C/18/20 as a predominantly positive, gene~~-~~specific submodule required for low transcription levels of nonactivated genes, including conjugation genes. The presented structure~~-~~based system perturbation is superior to gene deletion analysis of gene regulation.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18381891}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18381891 is the PubMed ID number.

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==About this Structure==

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[[Category: Transcription]]

[[Category: Transcription regulation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Apr 24 09~~:51:25 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:02:17 2008''

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-[[Image:3c0t.jpg|left|200px]]
+{{Seed}}
+[[Image:3c0t.png|left|200px]]
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 {{STRUCTURE_3c0t|  PDB=3c0t  |  SCENE=  }}
-'''Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18'''
+===Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18===
-==Overview==
+<!--
-A combination of crystallography, biochemistry, and gene expression analysis identifies the coactivator subcomplex Med8C/18/20 as a functionally distinct submodule of the Mediator head module. Med8C forms a conserved alpha-helix that tethers Med18/20 to the Mediator. Deletion of Med8C in vivo results in dissociation of Med18/20 from Mediator and in loss of transcription activity of extracts. Deletion of med8C, med18, or med20 causes similar changes in the yeast transcriptome, establishing Med8C/18/20 as a predominantly positive, gene-specific submodule required for low transcription levels of nonactivated genes, including conjugation genes. The presented structure-based system perturbation is superior to gene deletion analysis of gene regulation.
+The line below this paragraph, {{ABSTRACT_PUBMED_18381891}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18381891 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18381891}}
 ==About this Structure==
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 [[Category: Transcription]]
 [[Category: Transcription regulation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:51:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:02:17 2008''