3c45: Difference between revisions

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[[Image:3c45.jpg|left|200px]]
{{Seed}}
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{{STRUCTURE_3c45|  PDB=3c45  |  SCENE=  }}  
{{STRUCTURE_3c45|  PDB=3c45  |  SCENE=  }}  


'''Human dipeptidyl peptidase IV/CD26 in complex with a fluoroolefin inhibitor'''
===Human dipeptidyl peptidase IV/CD26 in complex with a fluoroolefin inhibitor===




==Overview==
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The synthesis, selectivity, rat pharmacokinetic profile, and drug metabolism profiles of a series of potent fluoroolefin-derived DPP-4 inhibitors (4) are reported. A radiolabeled fluoroolefin 33 was shown to possess a high propensity to form reactive metabolites, thus revealing a potential liability for this class of DPP-4 inhibitors.
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{{ABSTRACT_PUBMED_18331795}}


==About this Structure==
==About this Structure==
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[[Category: Signal-anchor]]
[[Category: Signal-anchor]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:52:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:44:58 2008''
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