6km7: Difference between revisions
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The | ==The structural basis for the internal interaction in RBBP5== | ||
<StructureSection load='6km7' size='340' side='right'caption='[[6km7]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6km7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KM7 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6km7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6km7 OCA], [http://pdbe.org/6km7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6km7 RCSB], [http://www.ebi.ac.uk/pdbsum/6km7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6km7 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/RBBP5_HUMAN RBBP5_HUMAN]] In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.<ref>PMID:19556245</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Chen, Y]] | |||
[[Category: Han, J]] | |||
[[Category: Li, T]] | |||
[[Category: Epigenetic]] | |||
[[Category: Histone methylation]] | |||
[[Category: Histone methyltransferase]] | |||
[[Category: Mll1 complex]] | |||
[[Category: Protein binding]] | |||
[[Category: Rbbp5]] | |||
Revision as of 10:25, 2 October 2019
The structural basis for the internal interaction in RBBP5
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