3c6t: Difference between revisions

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[[Image:3c6t.jpg|left|200px]]
{{Seed}}
[[Image:3c6t.png|left|200px]]


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{{STRUCTURE_3c6t|  PDB=3c6t  |  SCENE=  }}  
{{STRUCTURE_3c6t|  PDB=3c6t  |  SCENE=  }}  


'''Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14'''
===Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14===




==Overview==
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Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clinical mutations.
The line below this paragraph, {{ABSTRACT_PUBMED_18396399}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18396399 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18396399}}


==About this Structure==
==About this Structure==
3C6T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6T OCA].  
3C6T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Hiv-1_m:b_hxb2r Hiv-1 m:b_hxb2r]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6T OCA].  


==Reference==
==Reference==
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations., Tucker TJ, Saggar S, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y, Bioorg Med Chem Lett. 2008 Mar 25;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18396399 18396399]
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations., Tucker TJ, Saggar S, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y, Bioorg Med Chem Lett. 2008 Mar 25;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18396399 18396399]
[[Category: Human immunodeficiency virus 1]]
[[Category: Hiv-1 m:b_hxb2r]]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Prasad, S.]]
[[Category: Prasad, S.]]
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:52:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 08:56:33 2008''
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