3cf2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
Newer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_3cf2", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:3cf2.jpg|left|200px]]
{{Seed}}
[[Image:3cf2.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3cf2|  PDB=3cf2  |  SCENE=  }}  
{{STRUCTURE_3cf2|  PDB=3cf2  |  SCENE=  }}  


'''Structure of P97/vcp in complex with ADP/AMP-PNP'''
===Structure of P97/vcp in complex with ADP/AMP-PNP===




==Overview==
<!--
The ATPase p97/VCP affects multiple events within the cell. These events include the alteration of both nuclear and mitotic Golgi membranes, the dislocation of ubiquitylated proteins from the endoplasmic reticulum and regulation of the NF-kappa b pathway. Here we present the crystal structure of full-length Mus musculus p97/VCP in complex with a mixture of ADP and ADP-AlF(x) at a resolution of 4.7 A. This is the first complete hexameric structure of a protein containing tandem AAA (ATPases associated with a variety of cellular activities) domains. Comparison of the crystal structure and cryo-electron microscopy (EM) reconstructions reveals large conformational changes in the helical subdomains during the hydrolysis cycle. Structural and functional data imply a communication mechanism between the AAA domains. A Zn(2+) occludes the central pore of the hexamer, suggesting that substrate does not thread through the pore of the molecule.
The line below this paragraph, {{ABSTRACT_PUBMED_12949490}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12949490 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12949490}}


==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains., DeLaBarre B, Brunger AT, Nat Struct Biol. 2003 Oct;10(10):856-63. Epub 2003 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12949490 12949490]
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains., DeLaBarre B, Brunger AT, Nat Struct Biol. 2003 Oct;10(10):856-63. Epub 2003 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12949490 12949490]
Nucleotide dependent motion and mechanism of action of p97/VCP., DeLaBarre B, Brunger AT, J Mol Biol. 2005 Mar 25;347(2):437-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15740751 15740751]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 31: Line 37:
[[Category: Erad]]
[[Category: Erad]]
[[Category: Transport protein]]
[[Category: Transport protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:53:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 20 12:13:22 2008''

Revision as of 09:13, 20 August 2008

File:3cf2.png

Template:STRUCTURE 3cf2

Structure of P97/vcp in complex with ADP/AMP-PNP

Template:ABSTRACT PUBMED 12949490

About this Structure

3CF2 is a Single protein structure of sequence from Mus musculus. This structure supersedes the now removed PDB entry 1ypw. Full crystallographic information is available from OCA.

Reference

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains., DeLaBarre B, Brunger AT, Nat Struct Biol. 2003 Oct;10(10):856-63. Epub 2003 Aug 31. PMID:12949490

Nucleotide dependent motion and mechanism of action of p97/VCP., DeLaBarre B, Brunger AT, J Mol Biol. 2005 Mar 25;347(2):437-52. PMID:15740751

Page seeded by OCA on Wed Aug 20 12:13:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=3cf2&oldid=755298"