6gs9: Difference between revisions

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==NMR structure of aurein 2.5 in SDS micelles==
==NMR structure of aurein 2.5 in SDS micelles==
<StructureSection load='6gs9' size='340' side='right'caption='[[6gs9]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6gs9' size='340' side='right'caption='[[6gs9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6gs9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GS9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GS9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6gs9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ranoidea_aurea Ranoidea aurea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GS9 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gs9 OCA], [http://pdbe.org/6gs9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gs9 RCSB], [http://www.ebi.ac.uk/pdbsum/6gs9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gs9 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gs9 OCA], [https://pdbe.org/6gs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gs9 RCSB], [https://www.ebi.ac.uk/pdbsum/6gs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gs9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AUR25_RANAE AUR25_RANAE] Amphipathic alpha-helical antimicrobial peptide with moderate to potent activity against Gram-positive bacteria, Gram-negative bacteria and fungi (PubMed:10951191, PubMed:19056250, PubMed:23841919, PubMed:24728560, PubMed:31358802). Shows also a weak activity against biofilm of both Gram-positive and Gram-negative bacteria (PubMed:19056250). Probably acts by disturbing membrane functions with its amphipathic structure (PubMed:10951191, PubMed:23841919). Kills fungi via membranolytic action (PubMed:24728560). Enhanced sterol levels in lipid composition membranes reduce interaction of this peptide with membranes, having a protective effect against the lytic ability of the peptide (PubMed:24728560). Shows anticancer activity (PubMed:10951191).<ref>PMID:10951191</ref> <ref>PMID:19056250</ref> <ref>PMID:23841919</ref> <ref>PMID:24728560</ref> <ref>PMID:31358802</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Manzo, G]]
[[Category: Ranoidea aurea]]
[[Category: Mason, J A]]
[[Category: Manzo G]]
[[Category: Amp]]
[[Category: Mason JA]]
[[Category: Antimicrobial protein]]
[[Category: Aurein 2 5]]
[[Category: Sds micelle]]
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