6hj7: Difference between revisions

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==The NMR structure of NRADD death domain==
==The NMR structure of NRADD death domain==
<StructureSection load='6hj7' size='340' side='right'caption='[[6hj7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6hj7' size='340' side='right'caption='[[6hj7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6hj7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HJ7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6hj7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HJ7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nradd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj7 OCA], [https://pdbe.org/6hj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hj7 RCSB], [https://www.ebi.ac.uk/pdbsum/6hj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hj7 OCA], [http://pdbe.org/6hj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hj7 RCSB], [http://www.ebi.ac.uk/pdbsum/6hj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hj7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NRADD_MOUSE NRADD_MOUSE]] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.<ref>PMID:12728256</ref> <ref>PMID:12843241</ref> <ref>PMID:19407813</ref>
[https://www.uniprot.org/uniprot/NRADD_MOUSE NRADD_MOUSE] Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.<ref>PMID:12728256</ref> <ref>PMID:12843241</ref> <ref>PMID:19407813</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Arseniev, A S]]
[[Category: Arseniev AS]]
[[Category: Goncharuk, S A]]
[[Category: Goncharuk SA]]
[[Category: Mineev, K S]]
[[Category: Mineev KS]]
[[Category: Nadezhdin, K D]]
[[Category: Nadezhdin KD]]
[[Category: Bicelle]]
[[Category: Membrane protein]]
[[Category: Nraad]]
[[Category: P45]]
[[Category: P75 neurotrophin receptor]]
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