6nmt: Difference between revisions

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<StructureSection load='6nmt' size='340' side='right'caption='[[6nmt]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='6nmt' size='340' side='right'caption='[[6nmt]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6nmt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NMT FirstGlance]. <br>
<table><tr><td colspan='2'>[[6nmt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NMT FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nmr|6nmr]], [[6nms|6nms]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nmt OCA], [https://pdbe.org/6nmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nmt RCSB], [https://www.ebi.ac.uk/pdbsum/6nmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nmt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nmt OCA], [http://pdbe.org/6nmt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nmt RCSB], [http://www.ebi.ac.uk/pdbsum/6nmt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nmt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SHPS1_HUMAN SHPS1_HUMAN]] Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.<ref>PMID:10469599</ref> <ref>PMID:11509594</ref>
[https://www.uniprot.org/uniprot/SHPS1_HUMAN SHPS1_HUMAN] Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.<ref>PMID:10469599</ref> <ref>PMID:11509594</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6nmt" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6nmt" style="background-color:#fffaf0;"></div>
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Carter, J J]]
[[Category: Carter JJ]]
[[Category: Sim, J]]
[[Category: Sim J]]
[[Category: Wibowo, A S]]
[[Category: Wibowo AS]]
[[Category: Anti-sirp-alpha antibody]]
[[Category: Anti-sirp-alpha antibody in complex with sirp-alpha]]
[[Category: Blocking anti-sirp-alpha antibody]]
[[Category: Cd47]]
[[Category: Cluster of differentiation 47]]
[[Category: Immune system]]
[[Category: Kick-off anti-sirp-alpha antibody]]
[[Category: Non-blocking anti-sirp-alpha antibody]]
[[Category: Signal regulatory protein alpha]]
[[Category: Signal-regulatory protein alpha]]
[[Category: Sirp-alpha]]
[[Category: Tyrosine-protein phosphatase non-receptor type substrate 1]]
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