3chs: Difference between revisions

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[[Image:3chs.~~jpg~~|left|200px]]

[[Image:3chs.png|left|200px]]

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~~'''~~Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid~~'''~~

===Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid===

~~==Overview==~~

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~~Leukotriene B(4) (LTB(4)) is a potent pro-inflammatory mediator that has been implicated in the pathogenesis of multiple diseases~~, ~~including psoriasis~~, ~~inflammatory bowel disease, multiple sclerosis and asthma. As a method~~ to ~~decrease~~ the ~~level of LTB~~(4) ~~and possibly identify novel treatments~~, ~~inhibitors of~~ the ~~LTB(4) biosynthetic enzyme, leukotriene A(4) hydrolase (LTA(4)~~-~~h), have been explored. Here we describe the discovery of a potent inhibitor of LTA(4)~~-h, arylamide of glutamic acid 4f, starting from the corresponding glycinamide 2. Analogs of 4f are then described, focusing on compounds that are both active and stable in whole blood. This effort culminated in the identification of amino alcohol 12a and amino ester 6b which meet these criteria.

The line below this paragraph, {{ABSTRACT_PUBMED_18394906}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18394906 is the PubMed ID number.

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==About this Structure==

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[[Category: Multifunctional enzyme]]

[[Category: Zinc]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Apr 24 09~~:54:29 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:17:20 2008''

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-[[Image:3chs.jpg|left|200px]]
+{{Seed}}
+[[Image:3chs.png|left|200px]]
 <!--
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 {{STRUCTURE_3chs|  PDB=3chs  |  SCENE=  }}
-'''Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid'''
+===Crystal structure of leukotriene A4 hydrolase in complex with (2S)-2-amino-5-[[4-[(2S)-2-hydroxy-2-phenyl-ethoxy]phenyl]amino]-5-oxo-pentanoic acid===
-==Overview==
+<!--
-Leukotriene B(4) (LTB(4)) is a potent pro-inflammatory mediator that has been implicated in the pathogenesis of multiple diseases, including psoriasis, inflammatory bowel disease, multiple sclerosis and asthma. As a method to decrease the level of LTB(4) and possibly identify novel treatments, inhibitors of the LTB(4) biosynthetic enzyme, leukotriene A(4) hydrolase (LTA(4)-h), have been explored. Here we describe the discovery of a potent inhibitor of LTA(4)-h, arylamide of glutamic acid 4f, starting from the corresponding glycinamide 2. Analogs of 4f are then described, focusing on compounds that are both active and stable in whole blood. This effort culminated in the identification of amino alcohol 12a and amino ester 6b which meet these criteria.
+The line below this paragraph, {{ABSTRACT_PUBMED_18394906}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18394906 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18394906}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Multifunctional enzyme]]
 [[Category: Zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:54:29 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:17:20 2008''