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==Solution structure of the ZnF-UBP domain of USP20/VDU2==
==Solution structure of the ZnF-UBP domain of USP20/VDU2==
<StructureSection load='6kcz' size='340' side='right'caption='[[6kcz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6kcz' size='340' side='right'caption='[[6kcz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6kcz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5z4i 5z4i]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KCZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KCZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6kcz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5z4i 5z4i]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KCZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">USP20, KIAA1003, LSFR3A, VDU2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kcz OCA], [https://pdbe.org/6kcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kcz RCSB], [https://www.ebi.ac.uk/pdbsum/6kcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kcz ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kcz OCA], [http://pdbe.org/6kcz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kcz RCSB], [http://www.ebi.ac.uk/pdbsum/6kcz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kcz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UBP20_HUMAN UBP20_HUMAN]] Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12056827</ref> <ref>PMID:12865408</ref> <ref>PMID:15776016</ref> <ref>PMID:19424180</ref>
[https://www.uniprot.org/uniprot/UBP20_HUMAN UBP20_HUMAN] Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12056827</ref> <ref>PMID:12865408</ref> <ref>PMID:15776016</ref> <ref>PMID:19424180</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6kcz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6kcz" style="background-color:#fffaf0;"></div>
==See Also==
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ubiquitinyl hydrolase 1]]
[[Category: Wen Y]]
[[Category: Wen, Y]]
[[Category: Yang Y]]
[[Category: Yang, Y]]
[[Category: Zhang N]]
[[Category: Zhang, N]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/6kcz"