6qyn: Difference between revisions

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<StructureSection load='6qyn' size='340' side='right'caption='[[6qyn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='6qyn' size='340' side='right'caption='[[6qyn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6qyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QYN FirstGlance]. <br>
<table><tr><td colspan='2'>[[6qyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QYN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JL8:(2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic+acid'>JL8</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qxj|6qxj]], [[6qyk|6qyk]], [[6qyl|6qyl]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=JL8:(2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic+acid'>JL8</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qyn OCA], [https://pdbe.org/6qyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qyn RCSB], [https://www.ebi.ac.uk/pdbsum/6qyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qyn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qyn OCA], [http://pdbe.org/6qyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qyn RCSB], [http://www.ebi.ac.uk/pdbsum/6qyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qyn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).  
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6qyn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6qyn" style="background-color:#fffaf0;"></div>
==See Also==
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
*[[Maltose-binding protein 3D structures|Maltose-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cauquil, N]]
[[Category: Cauquil N]]
[[Category: Chen, I]]
[[Category: Chen I]]
[[Category: Csekei, M]]
[[Category: Csekei M]]
[[Category: Davidson, J]]
[[Category: Davidson J]]
[[Category: Davis, B]]
[[Category: Davis B]]
[[Category: Demarles, D]]
[[Category: Demarles D]]
[[Category: Dokurno, P]]
[[Category: Dokurno P]]
[[Category: Geneste, O]]
[[Category: Geneste O]]
[[Category: Hubbard, R E]]
[[Category: Hubbard RE]]
[[Category: Kotschy, A]]
[[Category: Kotschy A]]
[[Category: LeToumelin-Braizat, G]]
[[Category: LeToumelin-Braizat G]]
[[Category: Murray, J]]
[[Category: Murray J]]
[[Category: Ondi, L]]
[[Category: Ondi L]]
[[Category: Paczal, A]]
[[Category: Paczal A]]
[[Category: Pedder, C]]
[[Category: Pedder C]]
[[Category: Perron-Sierra, F]]
[[Category: Perron-Sierra F]]
[[Category: Radics, G]]
[[Category: Radics G]]
[[Category: Robertson, A]]
[[Category: Robertson A]]
[[Category: Smith, J]]
[[Category: Smith J]]
[[Category: Surgenor, A E]]
[[Category: Surgenor AE]]
[[Category: Szabo, Z B]]
[[Category: Szabo ZB]]
[[Category: Szlavik, Z]]
[[Category: Szlavik Z]]
[[Category: Zarka, M]]
[[Category: Zarka M]]
[[Category: Apoptosis]]
[[Category: Apoptosis-inhibitor complex]]
[[Category: Mbp]]
[[Category: Mcl1]]
[[Category: Small molecule inhibitor]]