2qzk: Difference between revisions

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New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_2qzk", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...
 
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[[Image:2qzk.jpg|left|200px]]
{{Seed}}
[[Image:2qzk.png|left|200px]]


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{{STRUCTURE_2qzk|  PDB=2qzk  |  SCENE=  }}  
{{STRUCTURE_2qzk|  PDB=2qzk  |  SCENE=  }}  


'''Crystal structure of human Beta Secretase complexed with I21'''
===Crystal structure of human Beta Secretase complexed with I21===




==Overview==
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This letter describes replacements for the P3 amide moiety present in previously reported tertiary carbinamine macrolactones. Although P-gp efflux issues associated with these amide-macrolactones were solved and full brain penetration was measured in one case, potency was compromised in the process.
The line below this paragraph, {{ABSTRACT_PUBMED_17827011}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17827011}}


==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:18:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:56:34 2008''
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