RNase P: Difference between revisions
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[[Image:6ah3_labeled_solid.png|left|400px]] | [[Image:6ah3_labeled_solid.png|left|400px]] | ||
== Function == | == Function == | ||
'''RNase P''' processing the 5′ end of pre-[[Transfer RNA (tRNA)|transfer RNAs]] as well as other RNA molecules.<ref>PMID:28697848</ref>. Most RNase Ps are complexes of proteins and RNAs, termed ribonucleoprotein (RNP) complexes; however, a few protein-only RNase Ps have been described.<ref>PMID:23322041</ref> | '''RNase P''' processing the 5′ end of pre-[[Transfer RNA (tRNA)|transfer RNAs]] as well as other RNA molecules.<ref>PMID:28697848</ref>. Most RNase Ps are complexes of proteins and RNAs, termed ribonucleoprotein (RNP) complexes; however, a few protein-only RNase Ps have been described.<ref>PMID:23322041</ref><ref>PMID:25780121/ref> | ||
In eukaryotes, the RNase P proteins have been found to have other roles. For example, many of the proteins are shared with a related RNase P, the small nucleolar RNase MRP, that is involved in processing ribosomal RNA.<ref>PMID:19395864</ref> In yeast, the proteins of RNase P also bind telomerase.<ref>PMID:27156450</ref> | In eukaryotes, the RNase P proteins have been found to have other roles. For example, many of the proteins are shared with a related RNase P, the small nucleolar RNase MRP, that is involved in processing ribosomal RNA.<ref>PMID:19395864</ref> In yeast, the proteins of RNase P also bind telomerase.<ref>PMID:27156450</ref> | ||
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Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme. | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme. | ||
'''RNP-based''' | |||
[[6agb]] - RNP-based RNase P - ''S. cerevisiae'' <br /> | [[6agb]] - RNP-based RNase P - ''S. cerevisiae'' <br /> | ||
[[6ah3]] - RNP-based RNase P bound to pre-tRNA substrate- ''S. cerevisiae'' <br /> | [[6ah3]] - RNP-based RNase P bound to pre-tRNA substrate- ''S. cerevisiae'' <br /> | ||
'''Protein-based''' | |||
Structural insights into protein-only RNase P complexed with tRNA | |||
