Transaldolase

spinqualitylabelsall models Transaldolase dimer complex with sedoheptulose 7-phosphate and Cl- (green) ion, 3tno Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Transaldolase (TAL) is part of the pentose phosphate pathway. It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate. See also Lysine-cysteine NOS bonds. Disease TAL deficiency influences mitochondrial homeostasis, Ca+2 fluxing and apoptosis. Structural highlights TAL overall structure is of a TIM barrel (Alpha Helices,  Beta Strands ,  Loops , Turns). The active site contains a Schiff-base-bound phosphosugar at Lys135. Water molecules are shown as red spheres. Cl coordination site.

3D Structures of transaldolase

Updated on 20-January-2022

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• Transaldolase
  • Lysine-cysteine NOS bonds – TAL – Neisseria gonorrhoeae
    
  • 3cwn, 1onr, 1ucw - EcTAL B – Escherichia coli
    
  • 3kof, 1i2n, 1i2o, 1i2p, 1i2q, 1i2r, 4rz5, 4rz6 - EcTAL B (mutant)
    
  • 3hjz – TAL B – Prochlorococcus marinus
    
  • 3igx, 4e0c – FtTAL B – Francisella tularensis
    
  • 3m16 – TAL – Oleispira Antarctica
    
  • 3r8r – TAL – Bacillus subtilis
    
  • 3r5e – TAL – Corynebacterium glutamicum
    
  • 1f05 – TAL – human
    
  • 1vpx – TAL – Thermotoga maritima
    
  • 1wx0 – TAL – Thermus thermophilus
    
  • 2cwn, 2e1d – TAL (mutant) – mouse
    
• Transaldolase binary complexes
  • 3tk7 - FtTAL B + fructose 6-phosphate
    
  • 3te9 - FtTAL B (mutant) + fructose 6-phosphate
    
  • 3tkf - FtTAL B (mutant) + seduheptulose 7-phosphate
    
  • 3tno - FtTAL B + seduheptulose 7-phosphate
    
  • 3upb - FtTAL B + arabinose 5-phosphate
    
  • 4s2b - EcTAL B + tagatose 6-phosphate
    
  • 4s2c, 4s1f - EcTAL B + fructose 6-phosphate
    
  • 4rxf, 4rxg, 4rz4 - EcTAL B (mutant) + fructose 6-phosphate
    
  • 4xz9 - TAL + glycerol 3-phosphate – Thermoplasma acidophilum
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman