Transducin: Difference between revisions

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== Disease ==
== Disease ==
Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.
Congenital stationary night blindness (Nougaret disease) is caused by a mutation in TDN α subunit<ref>PMID:8673138</ref>.
==3D structures of transducin==
[[Transducin 3D structures]]


</StructureSection>
</StructureSection>
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**[[1fqk]] – bTDN + RGS9 + GDP + AlF4<br />
**[[1fqk]] – bTDN + RGS9 + GDP + AlF4<br />
**[[1fqj]] – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4<br />
**[[1fqj]] – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4<br />
*Transducin-β
**[[6n9g]] – TDN + RGS7 - mouse<br />


*Transducin-βγ
*Transducin-βγ


**[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />
**[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
**[[6m8s]] – hTDN + KCTD12<br />
**[[6nbi]], [[6nbh]], [[6nbf]] – hTDN + PTH/PTHRP + long-acting parathyroid hormone + GS protein a subunit + nanobody – Cryo EM<br />
**[[4pnk]] – h/bTDN + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />
**[[1tbg]] – bTDN <br />
**[[1tbg]] – bTDN <br />
**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
**[[2trc]], [[1a0r]], [[1b9x]], [[1b9y]] – bTDN + phosducin<br />
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**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />
**[[3v5w]] – bTDN (mutant) + G-protein coupled receptor kinase 2<br />
**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />
**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bTDN + β-adrenergic receptor kinase 1<br />
**[[5he0]], [[5he1]], [[5he2]], [[5he3]], [[5ukk]], [[5ukl]], [[5ukm]] – hTDN + β-adrenergic receptor kinase 1 + inhibitor<br />
**[[4pnk]] – TDN hβ + bγ (mutant)+ β-adrenergic receptor kinase 1 + inhibitor<br />
**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />
**[[2bcj]] – bTDN (mutant) + β-adrenergic receptor kinase 1<br />
**[[3uzs]] – bTDN + β-adrenergic receptor kinase 1 + RNA<br />
**[[3uzs]] – bTDN + β-adrenergic receptor kinase 1 + RNA<br />
**[[3krw]], [[3krx]] – bTDN + G-protein coupled receptor kinase 2 + inhibitor<br />
**[[3krw]], [[3krx]], [[6c2y]], [[5wg5]], [[5wg4]], [[5wg3]] – bTDN + G-protein coupled receptor kinase 2 + inhibitor<br />
**[[1xhm]] – bTDN + peptide<br />
**[[1xhm]] – bTDN + peptide<br />
**[[4kfm]] – hTDN + G-protein activated inward rectifier K+ channel<br />
**[[6pcv]] – bTDN + RAC exchanger – Cryo EM<br />
**[[6b20]] – bTDN + nanobody<br />


*Transducin-α+βγ
*Transducin-α+βγ


**[[6eg8]] – hTDN + GDP<br />
**[[6ddf]], [[6dde]] – hTDN + mu opioid receptor + DAMGO – Cryo EM<br />
**[[6d9h]] – hTDN + AChR/adenosine receptor – Cryo EM<br />
**[[6p9x]] – hTDN + CRFR-1 + corticliberin – Cryo EM<br />
**[[6osa]] – hTDN + NTR1 + JMV449 – Cryo EM<br />
**[[6g79]] – hTDN + serotonin receptor – Cryo EM<br />
**[[6oy9]] – bTDN + rhodopsin + retinal – Cryo EM<br />
**[[6oya]] – bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
**[[1got]] – bTDN + GDP<br />
**[[1got]] – bTDN + GDP<br />
**[[1gg2]] – TDN rα (mutant) + bβγ + GDP - rat<br />
**[[1gp2]], [[5kdo]], [[1gg2]] – r/bTDN + GDP - rat<br />
**[[1gp2]], [[5kdo]] – TDN rα + bβγ + GDP <br />
**[[3ah8]] – r/bTDN (mutant) + GDP + inhibitor<br />
**[[3ah8]] – TDN rα + bβ + bγ (mutant) + GDP + inhibitor<br />
**[[5tdh]] – h/r/bTDN (mutant) + GDP<br />
**[[3sn6]] – TDN bα (mutant) + rβ (mutant) +bγ + endolysine + antibody fragment<br />
 
**[[5tdh]] – TDN hα (mutant) + rβ + bγ + GDP<br />
*Transducin-α+βγ complex with antibody
 
**[[6pt0]], [[6n4b]], [[6kpg]], [[6kpf]] – hTDN + cannaboid receptor + antibody fragment – Cryo EM<br />
**[[6pb1]], [[6pb0]] – hTDN + CRFR-2 + urocortin + nanobody – Cryo EM<br />
**[[6os9]] – hTDN + NTR1 + JMV449 + antibody fragment – Cryo EM<br />
**[[6oik]], [[6oij]] – hTDN + AChR + antibody fragment – Cryo EM<br />
**[[6crk]] – hTDN + antibody fragment <br />
**[[6niy]], [[6e3y]] – hTDN + calcitonin receptor + calcitonin + nanobody – Cryo EM<br />
**[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br />
**[[5uz7]] – hTDN + calcitonin receptor + antibody fragment - Cryo EM<br />
**[[5vai]] – TDN hα + rβ + bγ+ glucagon-like peptide + antibody fragment - Cryo EM<br />
**[[6ni3]] – hTDN + endolysin/adrenergic receptor + nanobody – Cryo EM<br />
**[[6omm]] – hTDN + formyl peptide receptor + peptide agonist + antibody fragment – Cryo EM<br />
**[[6p9y]] – hTDN + PACAP + nanobody – Cryo EM<br />
**[[6li3]] – hTDN + GPR52 + nanobody – Cryo EM<br />
**[[6gdg]] – hTDN + adenosine A2A receptor + nanobody – Cryo EM<br />
**[[6b3j]] – hTDN + GLP-1R + exendin-p5 + nanobody – Cryo EM<br />
**[[6ot0]] – hTDN + antibody + smoothened homolog – Cryo EM<br />
**[[6cmo]] – hTDN + antibody + rhodopsin/cytochrome b562 – Cryo EM<br />
**[[6qno]] – h/bTDN + antibody + rhodopsin + retinal – Cryo EM<br />
**[[5vai]] – h/r/bTDN + glucagon-like peptide + antibody fragment - Cryo EM<br />
**[[3sn6]] – TDN ba (mutant) + rb (mutant) + bc + endolysine + antibody fragment<br />
 
}}
}}
== References ==
== References ==
Retrieved from "https://proteopedia.org/Transducin"