Sandbox GGC9: Difference between revisions
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== ligands == | == ligands == | ||
The ligands that have a high affinity to the AR are Testosterone (T) and Dihydrotestosterone (DHT). Testosterone is a cholesterol derivative, this hormone helps facilitate male maturation and development. Dihydrotestosterone is a tissue metabolite of testosterone and is significantly more potent then testosterone. | The ligands that have a high affinity to the AR are Testosterone (T) and Dihydrotestosterone (DHT). Testosterone is a cholesterol derivative, this hormone helps facilitate male maturation and development. Dihydrotestosterone is a tissue metabolite of testosterone and is significantly more potent then testosterone. | ||
==binding pocket== | |||
The way AR binds the dozens of coregulator proteins reported to associate with different regions of AR are poorly understood. Nuclear receptors activate transcription by binding short sequences such as LxxLL or FXXLF (where “x” is any amino acid). these residues bid to the OH group on the testosterone and allow for pocket stabilization. | |||
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
<scene name='75/752271/1_ar_b_pocket_alpha_c_labeled/2'>Text To Be Displayed</scene> | |||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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== References == | == References == | ||
<references/> | <references/> | ||
1. Askew EB, Gampe RT Jr, Stanley TB, Faggart JL, Wilson EM. Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone. J Biol Chem. 2007;282(35):25801–25816. doi:10.1074/jbc.M703268200 | |||
2. Hur E, Pfaff SJ, Payne ES, Grøn H, Buehrer BM, Fletterick RJ. Recognition and accommodation at the androgen receptor coactivator binding interface. PLoS Biol. 2004;2(9):E274. doi:10.1371/journal.pbio.0020274 | |||
