1y4o: Difference between revisions

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[[Image:1y4o.gif|left|200px]]
{{Seed}}
[[Image:1y4o.png|left|200px]]


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{{STRUCTURE_1y4o|  PDB=1y4o  |  SCENE=  }}  
{{STRUCTURE_1y4o|  PDB=1y4o  |  SCENE=  }}  


'''Solution structure of a mouse cytoplasmic Roadblock/LC7 dynein light chain'''
===Solution structure of a mouse cytoplasmic Roadblock/LC7 dynein light chain===




==Overview==
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Roadblock/LC7 is a member of a class of dynein light chains involved in regulating the function of the dynein complex. We have determined the three-dimensional structure of isoform 1 of the mouse Roadblock/LC7 cytoplasmic dynein light chain (robl1_mouse) by NMR spectroscopy. In contrast to a previously reported NMR structure of the human homolog with 96% sequence identity (PDB 1TGQ), which showed the protein as a monomer, our results indicate clearly that robl1 exists as a symmetric homodimer. The two beta3-strands pair with each other and form a continuous ten-stranded beta-sheet. The 25-residue alpha2-helix from one subunit packs antiparallel to that of the other subunit on the face of the beta-sheet. Zipper-like hydrophobic contacts between the two helices serve to stabilize the dimer. Through an NMR titration experiment, we localized the site on robl1_mouse that interacts with the 40 residue peptide spanning residues 243 through 282 of IC74-1_rat. These results provide physical evidence for a symmetrical interaction between dimeric robl1 and the two molecules of IC74-1 in the dynein complex.
The line below this paragraph, {{ABSTRACT_PUBMED_16289575}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16289575}}


==About this Structure==
==About this Structure==
1Y4O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y4O OCA].  
1Y4O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y4O OCA].  


==Reference==
==Reference==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:23:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:13:21 2008''

Revision as of 11:13, 27 July 2008

File:1y4o.png

Template:STRUCTURE 1y4o

Solution structure of a mouse cytoplasmic Roadblock/LC7 dynein light chain

Template:ABSTRACT PUBMED 16289575

About this Structure

1Y4O is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of isoform 1 of Roadblock/LC7, a light chain in the dynein complex., Song J, Tyler RC, Lee MS, Tyler EM, Markley JL, J Mol Biol. 2005 Dec 16;354(5):1043-51. Epub 2005 Nov 2. PMID:16289575

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