6rir: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of phosphorylated Rab8a in complex with the Rab-binding domain of RILPL2== | |||
<StructureSection load='6rir' size='340' side='right'caption='[[6rir]], [[Resolution|resolution]] 1.77Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6rir]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RIR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RIR FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rir OCA], [http://pdbe.org/6rir PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rir RCSB], [http://www.ebi.ac.uk/pdbsum/6rir PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rir ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/RAB8A_HUMAN RAB8A_HUMAN]] May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.<ref>PMID:20890297</ref> <ref>PMID:21282656</ref> [[http://www.uniprot.org/uniprot/RIPL2_HUMAN RIPL2_HUMAN]] Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). May function via activation of RAC1 and PAK1 (By similarity).[UniProtKB:Q6AYA0][UniProtKB:Q99LE1] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Alessi, D R]] | |||
[[Category: Purlyte, E]] | [[Category: Purlyte, E]] | ||
[[Category: Waschbusch, D]] | [[Category: Waschbusch, D]] | ||
[[Category: | [[Category: Effector]] | ||
[[Category: Membrane trafficking]] | |||
[[Category: Rab gtpase]] | |||
[[Category: Signaling protein]] | |||
Revision as of 15:36, 29 January 2020
Crystal structure of phosphorylated Rab8a in complex with the Rab-binding domain of RILPL2
| ||||||||||||
