6ssd: Difference between revisions
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==Transaminase with PLP bound== | |||
<StructureSection load='6ssd' size='340' side='right'caption='[[6ssd]], [[Resolution|resolution]] 1.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ssd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_kaniharaensis Streptomyces kaniharaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SSD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ssd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ssd OCA], [https://pdbe.org/6ssd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ssd RCSB], [https://www.ebi.ac.uk/pdbsum/6ssd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ssd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A6I8WFW1_9ACTN A0A6I8WFW1_9ACTN] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin. Cycloserine is thought to inhibit PLP-dependent enzymes by irreversibly forming a PMP-isoxazole. We now report that ForI forms novel PMP-diketopiperazine derivatives following incubation with both d and l cycloserine. This unexpected result suggests chemical diversity in the chemistry of cycloserine inhibition. | |||
PMP-diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis.,Gao S, Liu H, de Crecy-Lagard V, Zhu W, Richards NGJ, Naismith JH Chem Commun (Camb). 2019 Nov 28;55(96):14502-14505. doi: 10.1039/c9cc06975e. PMID:31730149<ref>PMID:31730149</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6ssd" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Streptomyces kaniharaensis]] | |||
[[Category: Gao S]] | |||
[[Category: Naismith JH]] | |||
