6svl: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6svl is ~~ON HOLD~~

==human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6svl]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SVL FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6svl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6svl OCA], [http://pdbe.org/6svl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6svl RCSB], [http://www.ebi.ac.uk/pdbsum/6svl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6svl ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Ebenhoch, R]]

[[Category: Nar, H]]

[[Category: Cytokine]]

[[Category: Fab]]

[[Category: Growth factor]]

[[Category: Mydgf]]

[[Category: Neutralizing antibody]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6svl is ON HOLD
+==human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab==
+<StructureSection load='6svl' size='340' side='right'caption='[[6svl]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6svl]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SVL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SVL FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6svl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6svl OCA], [http://pdbe.org/6svl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6svl RCSB], [http://www.ebi.ac.uk/pdbsum/6svl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6svl ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Ebenhoch, R]]
+[[Category: Nar, H]]
+[[Category: Cytokine]]
+[[Category: Fab]]
+[[Category: Growth factor]]
+[[Category: Mydgf]]
+[[Category: Neutralizing antibody]]