6sws: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 6sws is ~~ON HOLD~~

==The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down regulation of inflammatory signalling through the Toll-like receptor pathway==

~~Authors~~: ~~Lauenstein~~, J.U., ~~Scherm~~, M.J.~~, Udgata, A~~., ~~Moncrieffe, M~~.C.~~, Fisher, D~~., ~~Gay, N~~.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[6sws]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SWS FirstGlance]. <br>

~~Description~~: ~~The DBB dimerization domain of~~ B-cell ~~adaptor for~~ PI3K ~~(BCAP~~) ~~is required~~ for ~~down regulation of inflammatory signalling through~~ the Toll-like receptor ~~pathway~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sws OCA], [http://pdbe.org/6sws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sws RCSB], [http://www.ebi.ac.uk/pdbsum/6sws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sws ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

[[Category: Moncrieffe, M.C]]

== Function ==

[[Category: ~~Lauenstein~~, J.U]]

[[http://www.uniprot.org/uniprot/BCAP_HUMAN BCAP_HUMAN]] Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.<ref>PMID:15893754</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Fisher, D]]

[[Category: Gay, N J]]

[[Category: Lauenstein, J U]]

[[Category: Moncrieffe, M C]]

[[Category: Scherm, M J]]

[[Category: Udgata, A]]

[[Category: ~~Gay, N.J~~]]

[[Category: Dbb]]

[[Category: ~~Scherm, M.J~~]]

[[Category: Tig/ipt]]

[[Category: ~~Fisher, D~~]]

[[Category: Transcription]]

[[Category: Transcription factor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6sws is ON HOLD
+==The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down regulation of inflammatory signalling through the Toll-like receptor pathway==
+<StructureSection load='6sws' size='340' side='right'caption='[[6sws]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Lauenstein, J.U., Scherm, M.J., Udgata, A., Moncrieffe, M.C., Fisher, D., Gay, N.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6sws]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SWS FirstGlance]. <br>
-Description: The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down regulation of inflammatory signalling through the Toll-like receptor pathway
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sws OCA], [http://pdbe.org/6sws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sws RCSB], [http://www.ebi.ac.uk/pdbsum/6sws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sws ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Moncrieffe, M.C]]
+== Function ==
-[[Category: Lauenstein, J.U]]
+[[http://www.uniprot.org/uniprot/BCAP_HUMAN BCAP_HUMAN]] Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.<ref>PMID:15893754</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Fisher, D]]
+[[Category: Gay, N J]]
+[[Category: Lauenstein, J U]]
+[[Category: Moncrieffe, M C]]
+[[Category: Scherm, M J]]
 [[Category: Udgata, A]]
-[[Category: Gay, N.J]]
+[[Category: Dbb]]
-[[Category: Scherm, M.J]]
+[[Category: Tig/ipt]]
-[[Category: Fisher, D]]
+[[Category: Transcription]]
+[[Category: Transcription factor]]