6u49: Difference between revisions
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==Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus== | |||
<StructureSection load='6u49' size='340' side='right'caption='[[6u49]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6u49]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U49 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PQJ:fos-choline-14'>PQJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6u3t|6u3t]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u49 OCA], [http://pdbe.org/6u49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u49 RCSB], [http://www.ebi.ac.uk/pdbsum/6u49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u49 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU]] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Kozhaya, L]] | |||
[[Category: Liu, J]] | |||
[[Category: Lu, M]] | [[Category: Lu, M]] | ||
[[Category: Torres, V J]] | |||
[[Category: Unutmaz, D]] | [[Category: Unutmaz, D]] | ||
[[Category: | [[Category: Alpha-toxin]] | ||
[[Category: | [[Category: Leukocidin]] | ||
[[Category: | [[Category: Mrsa]] | ||
[[Category: Pvl]] | |||
[[Category: Toxin]] | |||
Revision as of 10:20, 27 March 2020
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
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