6u7t

MutY adenine glycosylase bound to DNA containing a transition state analog (1N) paired with d(8-oxo-G)

spinqualitylabelsall models 6u7t, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6u7t is a 3 chain structure. This structure supersedes the now removed PDB entries 5dpk and 3fsq. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, SF4 NonStd Res: 8OG, NR1 Related: 6q0c Activity: Adenine glycosylase, with EC number 3.2.2.31 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [MUTY_GEOSE] Base excision repair (BER) glycosylase that initiates repair of A:oxoG to C:G by removing the inappropriately paired adenine base from the DNA backbone, generating an abasic site product (PubMed:25995449) (PubMed:14961129). 8-oxoguanine (oxoG) is a genotoxic DNA lesion resulting from oxidation of guanine; this residue is misread by replicative DNA polymerases, that insert adenine instead of cytosine opposite the oxidized damaged base. Shows a powerful dicrimination of A versus C, since it does not cleave cytosine in oxoG:C pairs (PubMed:25995449). May also be able to remove adenine from A:G mispairs, although this activity may not be physiologically relevant (PubMed:14961129).

Proteopedia Page Contributors and Editors (what is this?)

OCA