6uia: Difference between revisions
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==Structure of ATP citrate lyase with CoA in a partially open conformation== | |||
<StructureSection load='6uia' size='340' side='right'caption='[[6uia]], [[Resolution|resolution]] 4.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6uia]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UIA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_citrate_synthase ATP citrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.8 2.3.3.8] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uia OCA], [http://pdbe.org/6uia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uia RCSB], [http://www.ebi.ac.uk/pdbsum/6uia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uia ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: ATP citrate synthase]] | |||
[[Category: Large Structures]] | |||
[[Category: Ronen, M]] | |||
[[Category: Xuepeng, W]] | |||
[[Category: Lyase]] | |||
[[Category: Open conformation]] | |||
Revision as of 09:21, 25 December 2019
Structure of ATP citrate lyase with CoA in a partially open conformation
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