5nnh: Difference between revisions

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<StructureSection load='5nnh' size='340' side='right'caption='[[5nnh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5nnh' size='340' side='right'caption='[[5nnh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nnh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-8 Hhv-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NNH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nnh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NNH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nn7|5nn7]], [[5nnu|5nnu]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF46 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=37296 HHV-8])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnh OCA], [https://pdbe.org/5nnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nnh RCSB], [https://www.ebi.ac.uk/pdbsum/5nnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnh ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uracil-DNA_glycosylase Uracil-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.27 3.2.2.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nnh OCA], [http://pdbe.org/5nnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nnh RCSB], [http://www.ebi.ac.uk/pdbsum/5nnh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nnh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q76RG8_HHV8 Q76RG8_HHV8]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.[HAMAP-Rule:MF_04046]  
[https://www.uniprot.org/uniprot/UNG_HHV8P UNG_HHV8P] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.[HAMAP-Rule:MF_04046]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hhv-8]]
[[Category: Human gammaherpesvirus 8]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Uracil-DNA glycosylase]]
[[Category: Bagneris C]]
[[Category: Bagneris, C]]
[[Category: Barrett T]]
[[Category: Barrett, T]]
[[Category: Cole AR]]
[[Category: Cole, A R]]
[[Category: Earl C]]
[[Category: Earl, C]]
[[Category: Savva R]]
[[Category: Savva, R]]
[[Category: Hydrolase]]
[[Category: Uracil-dna glycosylase]]
Retrieved from "https://proteopedia.org/5nnh"