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| [[Image:3bzf.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_3bzf| PDB=3bzf | SCENE= }} | | {{STRUCTURE_3bzf| PDB=3bzf | SCENE= }} |
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| '''The human non-classical major histocompatibility complex molecule HLA-E'''
| | ===The human non-classical major histocompatibility complex molecule HLA-E=== |
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| ==Overview==
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| Human leukocyte antigen (HLA)-E is a non-classical major histocompatibility complex class I molecule that binds peptides derived from the leader sequences of other HLA class I molecules. Natural killer cell recognition of these HLA-E molecules, via the CD94-NKG2 natural killer family, represents a central innate mechanism for monitoring major histocompatibility complex expression levels within a cell. The leader sequence-derived peptides bound to HLA-E exhibit very limited polymorphism, yet subtle differences affect the recognition of HLA-E by the CD94-NKG2 receptors. To better understand the basis for this peptide-specific recognition, we determined the structure of HLA-E in complex with two leader peptides, namely, HLA-Cw*07 (VMAPRALLL), which is poorly recognised by CD94-NKG2 receptors, and HLA-G*01 (VMAPRTLFL), a high-affinity ligand of CD94-NKG2 receptors. A comparison of these structures, both of which were determined to 2.5-A resolution, revealed that allotypic variations in the bound leader sequences do not result in conformational changes in the HLA-E heavy chain, although subtle changes in the conformation of the peptide within the binding groove of HLA-E were evident. Accordingly, our data indicate that the CD94-NKG2 receptors interact with HLA-E in a manner that maximises the ability of the receptors to discriminate between subtle changes in both the sequence and conformation of peptides bound to HLA-E.
| | The line below this paragraph, {{ABSTRACT_PUBMED_18339401}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 18339401 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_18339401}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Transmembrane]] | | [[Category: Transmembrane]] |
| [[Category: Ubl conjugation]] | | [[Category: Ubl conjugation]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:34:21 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:39:38 2008'' |
