5ji3: Difference between revisions

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<StructureSection load='5ji3' size='340' side='right'caption='[[5ji3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5ji3' size='340' side='right'caption='[[5ji3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ji3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JI3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JI3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ji3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JI3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JI3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAT:2-DEOXYADENOSINE-5-DIPHOSPHATE'>DAT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g4a|1g4a]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAT:2-DEOXYADENOSINE-5-DIPHOSPHATE'>DAT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hslV, EC55989_4410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), hslU, htpI, Z5478, ECs4858 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ji3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ji3 OCA], [https://pdbe.org/5ji3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ji3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ji3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ji3 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HslU--HslV_peptidase HslU--HslV peptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.2 3.4.25.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ji3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ji3 OCA], [http://pdbe.org/5ji3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ji3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ji3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ji3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HSLV_ECO55 HSLV_ECO55]] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. [[http://www.uniprot.org/uniprot/HSLU_ECO57 HSLU_ECO57]] ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.  
[https://www.uniprot.org/uniprot/HSLV_ECOLI HSLV_ECOLI] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: HslU--HslV peptidase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Baytshtok, V]]
[[Category: Baytshtok V]]
[[Category: Grant, R A]]
[[Category: Grant RA]]
[[Category: Sauer, R T]]
[[Category: Sauer RT]]
[[Category: Schmitz, K R]]
[[Category: Schmitz KR]]
[[Category: Aaa+ atpase]]
[[Category: Hslvu]]
[[Category: Hydrolase]]
[[Category: Hydrolase complex]]
[[Category: Peptidase]]
[[Category: Peptidase-atpase complex]]
Retrieved from "https://proteopedia.org/5ji3"