5l81: Difference between revisions

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<StructureSection load='5l81' size='340' side='right'caption='[[5l81]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
<StructureSection load='5l81' size='340' side='right'caption='[[5l81]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5l81]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L81 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5l81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L81 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fermt3, Kind3, Urp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l81 OCA], [http://pdbe.org/5l81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l81 RCSB], [http://www.ebi.ac.uk/pdbsum/5l81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l81 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l81 OCA], [https://pdbe.org/5l81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l81 RCSB], [https://www.ebi.ac.uk/pdbsum/5l81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l81 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/URP2_MOUSE URP2_MOUSE]] Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (PubMed:18278053). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234461). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (PubMed:18278053).[UniProtKB:Q86UX7]<ref>PMID:18278053</ref> <ref>PMID:18662549</ref> <ref>PMID:19234461</ref>
[https://www.uniprot.org/uniprot/URP2_MOUSE URP2_MOUSE] Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (PubMed:18278053). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234461). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (PubMed:18278053).[UniProtKB:Q86UX7]<ref>PMID:18278053</ref> <ref>PMID:18662549</ref> <ref>PMID:19234461</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Gilbert, R J.C]]
[[Category: Gilbert RJC]]
[[Category: Harlos, K]]
[[Category: Harlos K]]
[[Category: Ni, T]]
[[Category: Ni T]]
[[Category: Integrin activation]]
[[Category: Membrane binding]]
[[Category: Pleckstrin homology domain]]
[[Category: Signaling protein]]