6j60: Difference between revisions

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<StructureSection load='6j60' size='340' side='right'caption='[[6j60]], [[Resolution|resolution]] 0.96&Aring;' scene=''>
<StructureSection load='6j60' size='340' side='right'caption='[[6j60]], [[Resolution|resolution]] 0.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6j60]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J60 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6j60]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J60 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j60 OCA], [http://pdbe.org/6j60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j60 RCSB], [http://www.ebi.ac.uk/pdbsum/6j60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j60 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 0.96&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j60 OCA], [https://pdbe.org/6j60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j60 RCSB], [https://www.ebi.ac.uk/pdbsum/6j60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j60 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Disease ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN] Amyotrophic lateral sclerosis;Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>  The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>  
Subcellular membrane-less organelles consist of proteins with low complexity domains. Many of them, such as hnRNPA1, can assemble into both a polydisperse liquid phase and an ordered solid phase of amyloid fibril. The former mirrors biological granule assembly, while the latter is usually associated with neurodegenerative disease. Here, we observe a reversible amyloid formation of hnRNPA1 that synchronizes with liquid-liquid phase separation, regulates the fluidity and mobility of the liquid-like droplets, and facilitates the recruitment of hnRNPA1 into stress granules. We identify the reversible amyloid-forming cores of hnRNPA1 (named hnRACs). The atomic structures of hnRACs reveal a distinct feature of stacking Asp residues, which contributes to fibril reversibility and explains the irreversible pathological fibril formation caused by the Asp mutations identified in familial ALS. Our work characterizes the structural diversity and heterogeneity of reversible amyloid fibrils and illuminates the biological function of reversible amyloid formation in protein phase separation.
== Function ==
 
[https://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.<ref>PMID:17229681</ref>  
Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly.,Gui X, Luo F, Li Y, Zhou H, Qin Z, Liu Z, Gu J, Xie M, Zhao K, Dai B, Shin WS, He J, He L, Jiang L, Zhao M, Sun B, Li X, Liu C, Li D Nat Commun. 2019 May 1;10(1):2006. doi: 10.1038/s41467-019-09902-7. PMID:31043593<ref>PMID:31043593</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6j60" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gui, X]]
[[Category: Gui X]]
[[Category: Li, D]]
[[Category: Li D]]
[[Category: Li, X]]
[[Category: Li X]]
[[Category: Liu, C]]
[[Category: Liu C]]
[[Category: Luo, F]]
[[Category: Luo F]]
[[Category: Zhou, H]]
[[Category: Zhou H]]
[[Category: Microed]]
[[Category: Phase separation]]
[[Category: Reversibility]]
[[Category: Rna binding protein]]
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