6t8h: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6t8h is ~~ON HOLD~~

==Cryo-EM structure of the DNA-bound PolD-PCNA processive complex from P. abyssi==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6t8h]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T8H OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T8H FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t8h OCA], [http://pdbe.org/6t8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t8h RCSB], [http://www.ebi.ac.uk/pdbsum/6t8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t8h ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PCNA_PYRAB PCNA_PYRAB]] Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non-specific cleavage.[HAMAP-Rule:MF_00317]<ref>PMID:22431731</ref> [[http://www.uniprot.org/uniprot/DP2S_PYRAB DP2S_PYRAB]] Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: DNA-directed DNA polymerase]]

[[Category: Large Structures]]

[[Category: Beaufet, I Hugonneau]]

[[Category: Carroni, M]]

[[Category: Delarue, M]]

[[Category: England, P]]

[[Category: Lindhal, E]]

[[Category: Madru, C]]

[[Category: Pehau-Arnaudet, G]]

[[Category: Raia, P]]

[[Category: Sauguet, L]]

[[Category: Dp1]]

[[Category: Dp2]]

[[Category: Pcna]]

[[Category: Pip-box]]

[[Category: Pold]]

[[Category: Replication]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6t8h is ON HOLD
+==Cryo-EM structure of the DNA-bound PolD-PCNA processive complex from P. abyssi==
+<StructureSection load='6t8h' size='340' side='right'caption='[[6t8h]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6t8h]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T8H FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t8h OCA], [http://pdbe.org/6t8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t8h RCSB], [http://www.ebi.ac.uk/pdbsum/6t8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t8h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PCNA_PYRAB PCNA_PYRAB]] Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non-specific cleavage.[HAMAP-Rule:MF_00317]<ref>PMID:22431731</ref>  [[http://www.uniprot.org/uniprot/DP2S_PYRAB DP2S_PYRAB]] Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: DNA-directed DNA polymerase]]
+[[Category: Large Structures]]
+[[Category: Beaufet, I Hugonneau]]
+[[Category: Carroni, M]]
+[[Category: Delarue, M]]
+[[Category: England, P]]
+[[Category: Lindhal, E]]
+[[Category: Madru, C]]
+[[Category: Pehau-Arnaudet, G]]
+[[Category: Raia, P]]
+[[Category: Sauguet, L]]
+[[Category: Dp1]]
+[[Category: Dp2]]
+[[Category: Pcna]]
+[[Category: Pip-box]]
+[[Category: Pold]]
+[[Category: Replication]]