6tar: Difference between revisions
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==Structure of the five-fold capsomer of the dArc1 capsid== | |||
<StructureSection load='6tar' size='340' side='right'caption='[[6tar]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6tar]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TAR FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tar OCA], [http://pdbe.org/6tar PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tar RCSB], [http://www.ebi.ac.uk/pdbsum/6tar PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tar ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ARC1_DROME ARC1_DROME]] Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer from motorneurons to muscles (PubMed:29328915). Arc1 protein is released from motorneurons in extracellular vesicles that mediate the transfer of Arc1 mRNA into muscle cells, where Arc1 mRNA can undergo activity-dependent translation (PubMed:29328915). Intercellular transfer od Arc1 mRNA is required for synaptic plasticity at the neuromuscular junction (PubMed:29328915). May play a role in energy balance: required for regulation of body fat by a specific population of brain neurons, named E347, that are necessary and sufficient for proper body fat storage (PubMed:26209258).<ref>PMID:26209258</ref> <ref>PMID:29328915</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Briggs, J A.G]] | |||
[[Category: Erlendsson, S]] | |||
[[Category: Morado, D R]] | |||
[[Category: Shepherd, J D]] | |||
[[Category: Darc]] | |||
[[Category: Gag]] | |||
[[Category: Virus]] | |||
[[Category: Virus like particle]] | |||
[[Category: Vlp]] | |||
Revision as of 08:25, 1 January 2020
Structure of the five-fold capsomer of the dArc1 capsid
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