1pvo: Difference between revisions

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[[Image:1pvo.gif|left|200px]]
{{Seed}}
[[Image:1pvo.png|left|200px]]


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{{STRUCTURE_1pvo|  PDB=1pvo  |  SCENE=  }}  
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'''X-ray crystal structure of Rho transcription termination factor in complex with ssRNA substrate and ANPPNP'''
===X-ray crystal structure of Rho transcription termination factor in complex with ssRNA substrate and ANPPNP===




==Overview==
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In bacteria, one of the major transcriptional termination mechanisms requires a RNA/DNA helicase known as the Rho factor. We have determined two structures of Rho complexed with nucleic acid recognition site mimics in both free and nucleotide bound states to 3.0 A resolution. Both structures show that Rho forms a hexameric ring in which two RNA binding sites--a primary one responsible for target mRNA recognition and a secondary one required for mRNA translocation and unwinding--point toward the center of the ring. Rather than forming a closed ring, the Rho hexamer is split open, resembling a "lock washer" in its global architecture. The distance between subunits at the opening is sufficiently wide (12 A) to accommodate single-stranded RNA. This open configuration most likely resembles a state poised to load onto mRNA and suggests how related ring-shaped enzymes may be breached to bind nucleic acids.
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{{ABSTRACT_PUBMED_12859904}}


==About this Structure==
==About this Structure==
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[[Category: Skordalakes, E.]]
[[Category: Skordalakes, E.]]
[[Category: Rho-anppnp-ssrna complex]]
[[Category: Rho-anppnp-ssrna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:55:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:35:32 2008''

Revision as of 14:35, 28 July 2008

File:1pvo.png


Drag the structure with the mouse to rotate
1pvo, resolution 3.00Å (default scene)
Ligands: ANP
Gene: RHO (Escherichia coli)
Related: 1pv4
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



X-ray crystal structure of Rho transcription termination factor in complex with ssRNA substrate and ANPPNP

Template:ABSTRACT PUBMED 12859904

About this Structure

1PVO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading., Skordalakes E, Berger JM, Cell. 2003 Jul 11;114(1):135-46. PMID:12859904

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